916-91 Recombinant Endotoxin-binding Protein (rBPI23) Attenuates Endotoxin-induced Circulatory Changes in Humans
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چکیده
منابع مشابه
Recombinant human activated protein C attenuates endotoxin-induced lung injury in awake sheep
INTRODUCTION Acute lung injury often complicates severe sepsis. In gram-negative sepsis, bacterial endotoxin activates both coagulation and inflammation. Enhanced lung vascular pressures and permeability, increased extravascular lung water content and deteriorated gas exchange characterize ovine endotoxin-induced lung injury, a frequently used model of acute lung injury. Recombinant human activ...
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Bacterial lipopolysaccharide induces tyrosine phosphorylation of paxillin, actin reorganization, and opening of the transendothelial paracellular pathway through which macromoles flux. In this study, lipid A was shown to be the bioactive portion of the lipopolysaccharide molecule responsible for changes in endothelial barrier function. We then studied whether endotoxin-neutralizing protein, a r...
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Interaction between human platelets and platelet plasma membrane with apparent bacterial endotoxin was studied in vitro attempts at repair, pseudopod formation, with transmission and scanning electron and centralization of platelet organdIes. microscopy. Washed human platelets, Copper appeared to potentiate these phewhose aggregation was blocked with nomena, since neither Cu2+ at low concenapyr...
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The aim of the present study was to investigate the efficacy of luteolin on endotoxin-induced uveitis (EIU) in rats. EIU was induced in Lewis rats by subcutaneous injections of lipopolysaccharide (LPS). One hr before the LPS injection, 0.1, 1 or 10 mg/kg luteolin or 1 mg/kg prednisolone was intraperitoneally injected. We investigated its effect upon clinical scores, cellular infiltration and pr...
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PURPOSE Investigation of physiological anti-inflammatory mechanisms can contribute to the treatment of inflammatory disorders. The purpose of the present study was to investigate the effect of nicotine, a selective cholinergic agonist, on endotoxin-induced uveitis (EIU) in rats and the underlying molecular mechanism. METHODS Lipopolysaccharide (LPS; endotoxin) and nicotine were injected intra...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1995
ISSN: 0735-1097
DOI: 10.1016/0735-1097(95)91768-s